Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
Visas titlar 101-120 av 570
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Patient Perspectives brought to the Fore for Diabetes Care: Descriptions as well as Development and Testing of the Diabetes Questionnaire
(2019-11-07)Aim: The overall aims were to describe perspectives of living with diabetes, to develop a patient-reported outcome and experience measure for the Swedish National Diabetes Register, and to initiate the evaluation of evidence ... -
Cardiac abnormalities in chronic kidney disease
(2019-11-06)Chronic kidney disease (CKD) is a global health problem associated with increased risk of mortality and development of end-stage renal disease (ESRD). Cardiovascular diseases are the leading cause of morbidity and mortality ... -
Energy metabolism and angiogenesis in atherosclerosis and cancer
(2019-10-30)Energy metabolism requires supply of glucose and oxygen. In atherosclerotic plaques and cancer tumors, there are local areas with mismatch in demand and supply of oxygen and nutrients. The resulting cellular energy imbalance ... -
Risk Factors and Predictors of Heart Failure: from Incidence to Prognosis
(2019-10-30)Background: Heart failure (HF) is a major public health problem affecting at least 26 million people worldwide and one of the leading causes of disability and death. Aims: To identify characteristics associated with ... -
Estrogen receptor α and Bone – Posttranslational modifications and cell-specific deletion
(2019-10-30)Estrogen is involved in the regulation and development of reproductive organs. In addition, estrogen regulates several other organs including the skeleton, immune system, and adipose tissue. Estrogen treatment protects ... -
Classification, care-seeking behaviour and pre-hospital triage of patients exposed to whiplash trauma
(2019-10-28)Classification, care-seeking behaviour and pre-hospital triage of patients exposed to a whiplash trauma Artur Tenenbaum Avdelning för samhällsmedicin och folkhälsa, Institutionen för medicin, Sahlgrenska akademin, ... -
Symptom patterns in irritable bowel syndrome
(2019-10-23)Who has never had them: symptoms in the abdominal region, such as pain, bloating, constipation, and diarrhoea? These are common symptoms of irritable bowel syndrome (IBS). IBS affects 5-10% of the population, especially ... -
A prospective chohort study on bone formation and bone loss in ankylosing spondylitis
(2019-10-02)Background and objectives: Patients with ankylosing spondylitis (AS) have an increased risk of bone loss with development of osteoporosis and vertebral fractures (VFs) but also spinal new bone formation with growth of bony ... -
Register-based evaluation of primary care - Focus on chronic disease
(2019-09-19)Background: Options for following up primary care at the regional level have increased in Sweden, partly as a result of a national reform in 2009. In Region Västra Götaland (VGR) this was the starting point for a quality ... -
Diseases in the hip - Exploring risk for fracture and osteoarhritis
(2019-09-18)Objective: Hip fracture is the most serious condition linked to low bone mass or osteoporosis, and Sweden has one of the highest incidences in the world. The proportion of elderly is increasing in the Swedish population ... -
Work-related cardiovascular disease
(2019-09-02)The overall aim of this thesis was to study occupational risk factors for cardiovascular disease, particularly, occupational noise, job strain and shift work. Incidence of cardiovascular disease was analysed in a general ... -
Statins, Lipids, and Mutations: Consequences for the Heart and Immune System
(2019-08-14)CAAX proteins are a group of proteins that undergo a three-step protein maturation process that renders the proteins carboxyl-terminus hydrophobic and prone to localize to cellular membranes, where they have their primary ... -
Samverkan vid vårdplanering för patienter med komplexa behov – ett mellanorganisatoriskt triangeldrama
(2019-05-22)Aims: The overall aim of this thesis was to deepen the knowledge of collaboration in care planning across healthcare provider boundaries for patients with complex care needs. Specific aims were: to highlight specialist ... -
Impact of chronic total occlusions, arterial access site, and pretreatment with antiplatelet drugs on mortality in patients with ischemic heart disease: A report from the SWEDEHEART registry.
(2019-05-17)Impact of chronic total occlusions, arterial access site and pretreatment with antiplatelet drugs on mortality in patients with ischemic heart disease: A report from the SWEDEHEART registry Background Treatment of ischemic ... -
Effects of gastric bypass surgery in patients with obesity and type 2 diabetes
(2019-05-17)Background: The effects of Roux-en-Y gastric bypass (GBP) have not been adequately explored in patients with concurrent obesity and type 2 diabetes mellitus (T2DM) to the same extent as has occurred for individuals with ... -
Work ability and exposure to work demands among workers with neck pain
(2019-05-13)Neck pain is one of the most common musculoskeletal disorders, which causes sickness absence and early retirement. Manual labor, awkward postures and repetitive work are commonly reported as causes for work-related neck ... -
Thymic studies. Investigations into the effects of childhood thymectomy, and characterization of thymic B cells and Hassall's corpuscles
(2019-04-23)This thesis focuses on the human thymus, a primary lymphoid organ responsible for the maturation of T cells. Progenitors arrive from the bone marrow and start to randomly assemble their T cell receptor (TCR) followed by a ... -
Smoking and T cell co-stimulation in rheumatoid arthritis
(2019-04-18)In this thesis I investigated if smoking limits the co-stimulatory system of CD8+ T cells in rheumatoid arthritis (RA). I took special interest in the co-inhibitory receptor PD-1 and its ligand PD-L1. Blood samples from ... -
B cell subpopulations in the pathogenesis of rheumatoid arthritis
(2019-04-04)B cell depleting therapy has proven to be an effective treatment in rheumatoid arthritis (RA), a disease characterized by the presence of autoantibodies against citrullinated proteins (ACPA) and the Fc portion of IgG ... -
Female genital Graft-versus-Host Disease - Diagnosis, Treatment, Incidence, Long-term Prevalence, and Impact on Androgen Hormones and Sexual Function
(2019-03-28)ABSTRACT BACKGROUND. Chronic graft-versus-host disease (cGvHD) is the major cause of morbidity after allogeneic hematopoietic stem cell transplantation (alloSCT), and contributes to non-relapse mortality. Caused by donor ...