Doctoral Theses / Doktorsavhandlingar Institutionen för medicin: Recent submissions
Visas titlar 141-160 av 570
-
Microbial modulation of metabolic diseases
(2018-09-13)The gut microbiota, the ensemble of microorganisms living in the gastrointestinal tract, and the host have a mutualist relationship. Alterations of this delicate equilibrium can lead to changes in microbiota composition ... -
Chemokine responses and T cell recruitment in central nervous system alphaherpesvirus infections
(2018-08-29)This thesis is focused on members of the alphaherpesvirus family; the two herpes simplex viruses and varicella zoster virus. Herpes simplex virus type 1 mainly causes cold sores and type 2 gives rise to genital blisters. ... -
STK25 as a regulator of lipid accumulation
(2018-08-24)Type 2 diabetes mellitus (T2DM) and nonalcoholic steatohepatitis (NASH), a progressive form of nonalcoholic fatty liver disease (NAFLD), have become widespread metabolic disorders that have reached epidemic proportions. ... -
Priority setting in health care and public health. The role of health economics
(2018-08-23)The aim of this thesis is to analyze the role of health economics for priority setting in health care and public health. Four papers provide the basis for the analysis. Paper I contains an application of a typical ... -
Cardiovascular health promotion among Nepalese mothers with young children: Need assessment, development, implementation, and impact of the HARDIC trial
(2018-06-07)Background Nutritional transition toward a high-fat and high-energy diet, decreasing physical activity level, and poor knowledge about cardiovascular health contribute to a rising burden of cardiovascular disease in ... -
Evaluating benefits and harms of screening - the streetlight effect?
(2018-05-25)The general aim of this thesis was to explore how the benefits and harms of screening for a potentially life-threatening disease can be evaluated. Papers I and II are a Cochrane Systematic Review on screening for malignant ... -
Hearing-related symptoms among women - Occurrence and risk in relation to occupational noise and stressful working conditions
(2018-05-24)A considerable amount of research has been devoted to the risk of noise-induced hearing loss among industry workers – the majority of whom are men. Much less research has been done in female-dominated human service ... -
Stratification and model-based analysis of patients with Irritable Bowel Syndrome using advanced biostatistics and medical data mining techniques
(2018-05-24)ABSTRACT Irritable Bowel Syndrome (IBS) is characterized by symptoms that are dominated by abdominal pain and abnormal bowel habits, as defined by the Rome criteria. The complexity of the disorder is exemplified by the ... -
Investigating antenatal care services, intimate partner violence and non-psychotic mental health disorders among postpartum women in Rwanda
(2018-05-22)Although maternal mortality has decreased in the past years and more women visit antenatal care (ANC) services during pregnancy in Rwanda, initiation and completion of the recommended number of visits remain a problem. It ... -
Addison's Disease and Type 1 Diabetes Mellitus
(2018-05-18)Background: Patients with type 1 diabetes (T1DM) and patients with Addison’s disease (AD) need life-long replacement therapy with insulin and glucocorticoids (GCs), respectively. Both groups have reduced life-expectancy. ... -
Renal function in cardiac surgery - Clinical and experimental studies
(2018-05-14)Background: Impaired renal function (measured as glomerular filtration rate (GFR)) is a well-known problem after heart surgery and heart transplantation (HTx), affecting both short-term and long-term survival. The reason ... -
Function of Surface-Associated Protein and DNA on Extracellular Vesicles
(2018-05-09)Extracellular vesicles (EVs), including exosomes, are nano-sized, lipid bilayer enclosed vesicles that are released into the extracellular environment from by almost all cells. EVs contain biomolecules, such as proteins, ... -
Irritable bowel syndrome and physical activity
(2018-05-07)Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. It is characterized by abdominal pain or discomfort associated with altered bowel habits. The symptoms of IBS limit the patients in daily ... -
Registry studies on myelodysplastic syndrome and secondary acute myeloid leukemia
(2018-04-18)The aims were (I) to describe a European lower risk MDS population and the use of erythropoietin stimulation agents (ESA), (II) to describe the AML population in Sweden 1997-2006 with emphasis on secondary AML (s-AML) and ... -
ILC2s and miRNA regulation in allergy and asthma
(2018-04-12)Asthma is a common respiratory disease that is characterized by chronic inflammation of the airways. In most asthmatic subjects, the immune response is driven by pro-inflammatory type 2 cytokines (interleukin (IL)-4, IL-5 ... -
Heart failure and type 1 diabetes
(2018-03-27)Background: Approximately 45,000 individuals live with type 1 diabetes (T1D) in Sweden. Previous studies have shown an increased risk for heart failure in persons with diabetes, but most of the studies have been in the ... -
Identification and early detection of cancer patients in primary care
(2018-03-21)Aim The aim of this thesis was to investigate how general practitioners (GP) can identify patients in primary care with potential common cancers, at an early stage. It was also to design a risk assessment tool for colorectal ... -
Hypertension, Atrial Fibrillation and Aldosteronism - A study of interplay, predictors and outcome
(2018-03-12)Background: Atrial fibrillation (AF) is the most common significant arrhythmia, affecting almost 3% of the adult population in Sweden. Although AF is associated with increased risk of lower quality of life, heart failure, ... -
Endosonography and pretreatment tumor profiling - from sampling, staining, to sequencing
(2018-03-01)Background and aims: Endosonography-guided fine needle aspiration (EUS-FNA) is imperfect in diagnosing solid pancreatic lesions (SPL) and subepithelial lesions (SEL) including gastrointestinal stromal tumors (GIST). In ... -
Counting deaths, accounting for lives
(2018-02-06)Half of the world’s deaths and their causes are never recorded by virtue of the under-resourced civil registration and vital statistics (CRVS) systems which limits capacity of health systems to respond to population needs. ...